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Alpha Lipoic Acid
Research and Studies
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Neuroprotection by the Metabolic
Antioxidant Alpha-Lipoic Acid |
| Lester Packer,
Hans J. Tritschler and Klaus Wessel |
Department of Molecular
and Cell Biology, University of California, Berkeley, CA
94720-3200 USA
ASTA Medica AG, 45 Weismullerstraße, D-60314, Frankfurt am
Main, Germany
Received 19 December 1996; revised 6 May 1996; accepted 6
May 1996. Available online 27 August 1998. |
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Memory loss in old rats is
associated with brain mitochondrial decay and RNA/DNA
oxidation: Partial reversal by feeding acetyl-L-carnitine
and/or R-Alpha-lipoic acid |
|
Jiankang Liu, Elizabeth Head, Afshin M. Gharib,
Wenjun Yuan, Russell T. Ingersoll*,
Tory M. Hagen, Carl W. Cotman, and Bruce N. Ames
|
| Division of Biochemistry
and Molecular Biology, University of California, Berkeley,
CA 94720; Children's Hospital Oakland Research Institute,
5700 Martin Luther King, Jr., Way, Oakland, CA 94609;
Institute for Brain Aging and Dementia, University of
California, Irvine, CA 92697-4540; and § Department
of Biochemistry and Biophysics, Linus Pauling Institute,
Oregon State University, Corvallis, OR 97331 |
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The antioxidants α-lipoic
acid and N-acetylcysteine reverse memory impairment
and brain oxidative stress in aged SAMP8 mice |
|
Susan A. Farr,*,†*Geriatric
Research Education and Clinical Center (GRECC), VA Medical
Center, St. Louis, Missouri, USA
†Department of Internal
Medicine, Division of Geriatric Medicine, St. Louis
University School of Medicine, St. Louis, Missouri, USA,
H. Fai Poon,‡‡Department
of Chemistry, Center of Membrane Sciences, and Sander-Brown
Center on Aging, University of Kentucky, Lexington,
Kentucky, USA, Dilek
Dogrukol-Ak,§§Anadolu
University, Faculty of Pharmacy, Department of Analytical
Chemistry, Eskisehir, Turkey,
Jeniffer Drake,‡‡Department
of Chemistry, Center of Membrane Sciences, and Sander-Brown
Center on Aging, University of Kentucky, Lexington,
Kentucky, USA, William
A. Banks,**Geriatric
Research Education and Clinical Center (GRECC), VA Medical
Center, St. Louis, Missouri, USA,
Edward Eyerman,**Geriatric
Research Education and Clinical Center (GRECC), VA Medical
Center, St. Louis, Missouri, USA,
D. Allan Butterfield‡‡Department
of Chemistry, Center of Membrane Sciences, and Sander-Brown
Center on Aging, University of Kentucky, Lexington,
Kentucky, USA and,
John E. Morley**Geriatric
Research Education and Clinical Center (GRECC), VA Medical
Center, St. Louis, Missouri, USA |
| Geriatric
Research Education and Clinical Center (GRECC), VA Medical
Center, St. Louis, Missouri, USA
†Department of Internal
Medicine, Division of Geriatric Medicine, St. Louis
University School of Medicine, St. Louis, Missouri, USA
‡Department of Chemistry, Center of
Membrane Sciences, and Sander-Brown Center on Aging,
University of Kentucky, Lexington, Kentucky, USA
§Anadolu
University, Faculty of Pharmacy, Department of Analytical
Chemistry, Eskisehir, Turkey |
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