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Centrophenoxine increases the rates of total and mRNA synthesis in
the brain cortex of old rats: an explanation of its action in terms
of the membrane hypothesis of aging.
Zs-Nagy I,
Semsei I.
The rates of total and polyA+ RNA
(mRNA) synthesis were measured by radioisotope technique in the
brain cortex of female CFY rats. There was practically no
significant difference between the young (1.5 months) and adult (13
months) rats; however, the old group (26 months) displayed a
considerable decrease of the rates of synthesis of both classes of
RNA studied. Centrophenoxine treatment (100 mg per kg body weight
per day, for 2 months) reversed this tendency, and increased
significantly the synthesis rates of old rats almost to the adult
level. The results are interpreted in terms of the membrane
hypothesis of aging, attributing a free-radical scavenger function
of the dimethylamino-ethanol incorporated into the nerve cell
membrane from the centrophenoxine.
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