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Effects of oxiracetam on learning and memory in animals: comparison with piracetam.
Mondadori C, Classen W, Borkowski
J, Ducret T, Buerki H, Schadé A The effects of
oxiracetam and piracetam were compared in learning and memory tests
in rats and mice. In the dose range examined, the two nootropics
were equally active in reducing the amnesia induced by cerebral
electroshock in the mouse. Step-down retention performance, however,
was distinctly improved by oxiracetam but unaffected by piracetam,
no matter whether it was given before or immediately after the
learning trial. Oxiracetam also improved acquisition performance in
aged (24- to 27-month-old) rats in an active-avoidance situation at
doses of 30 and 100 mg/kg i.p. whereas piracetam showed no effect at
100 mg/kg i.p.
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