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Oxiracetam prevented the scopolamine but not the diazepam induced
memory deficits in mice.
Hlinák Z, Krejcí I
Institute of Physiology, Academy
of Sciences of the Czech Republic, Vídenská 1083, 142 20 Prague 4,
Czech Republic.
In mice, the elevated plus-maze paradigm was used to investigate the
effect of scopolamine hydrobromide and diazepam and their
interaction with oxiracetam on the retrieval of spatial memory
trace. This paradigm measures (using the transfer latency) an
animal's capacity to escape from the open arm to the enclosed one.
The retention session followed 24 h after the acquisition one.
Experiment 1: Scopolamine (0.25 and 0.5 mg/kg) and diazepam (0.5 and
1.0 mg/kg) given 30 min before the retention session significantly
prolonged the transfer latency as compared with the saline treated
mice and those given the lowest dose of scopolamine (0.125 mg/kg)
and diazepam (0.25 mg/kg). Experiment 2: Oxiracetam administered at
doses of 3, 10 and 30 mg/kg immediately after the acquisition
session prevented the scopolamine induced prolongation of the
transfer latency. Thus, oxiracetam forestalled the impairment of
retrieval of memory trace: the animals were able to remember the
spatial configuration of the plus-maze. On the contrary, oxiracetam
was not effective in the diazepam treated mice. We suggest that
beneficial effect of oxiracetam might be confounded or blocked by
the anxiolytic effect of diazepam.
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