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The effect of nootropic agents on brain mitochondrial function in the dynamics of craniocerebral trauma from the age aspect Novikov VE, Kovaleva LA Smolensk Medical Academy, Russia.
Eksp
Klin Farmakol. 1998 Mar-Apr;61(2):65-8. A craniocerebral
trauma was modelled in experiments on one-month-old rats. Oxidative
phosphorylation in the brain mitochondria was studied by
polarography 1, 4, 7 days and 4 weeks after the trauma. In the
posttraumatic period the animals received piracetam (1 g/kg),
picamilon (500 mg/kg), pyriditol (100 mg/kg), pantogam (160 mg/kg),
ACTH (5-10) (0.1 mg/kg), nooglutyl (25 mg/kg), and GVS (0.5 mg/kg).
It was found that piracetam, picamilon, and nooglutyl have a
protective effect on the function of the brain mitochondria during
the course of a craniocerebral trauma. Nooglutyl surpasses all the
other drugs in its influence on the effectiveness of oxidative
phosphorylation of mitochondria in immature rats in the
posttraumatic period.
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